VSV Replication and M Protein

[Michael Nichols]

In Rhabdoviridae (specifically VSV) when the (-) strand is transcribed 
(copied? changed?) to (+) strand RNA, it is subsequently either used as 
a template to make further (-) strand, or it is selectively transcribed. 
My question is: if the M protein's binding to the leader sequence is an 
important factor in the decision of the polymerase to make full strand 
(or to bugger off at one ot the intergenic sequences) is the resulting 
full (+) strand coated with M protein ? If so, what is the mechanism for 
uncoating the (+) strand to produce a (-) full length strand suitable 
for packaging.

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                        mfbnicho @ is.dal.ca
                         -      OR       -
                        1650 Walnut St.
                        Halifax, Nova Scotia
                        CANADA  B3H 3S4
                        (902) 423-0153
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