Immune cell mediated anti-viral apoptosis?

[DANDERSON at PRL.PULMONARY.UBC.CA]

LANSMAN at vaxa.cis.uwosh.edu wrote:

>I think that viruses which cause apoptosis do so by accident.  They 
>may be in a host or cell type to which they are not well adapted.  

Why could not a cell which is infected with a virus which has not evolved to 
inhibit apoptosis (like adenoviruses and papilomaviruses do),  
undergoing  CD4+ T-cell (fas/fas-ligand)  mediated apoptosis which is 
anti-viral?  

The receptor/ligand pairs of TNF family members regulate 
cell death through apoptosis, both positively and negatively. 
(Lederman S et al.  Current Opinions in Immunology  1993,  5:439-444) 
Therefore, should not the anti-viral effects of the TNF family of ligands and 
receptors [TNF-alpha, TNF- beta,CD40/CD40 ligand ("CD40 ligand has 
potent anti-viral activity."  Nature Medicine, May 1995)] also be 
considered as regulators of apoptosis during viral infection?

Dan Anderson