Regarding the infectivity of naked DNA

[Jorg Kirberg]

In article <3pvalu$e33 at cisunix1.dfci.harvard.edu>,
york at mbcrr.dfci.harvard.edu (Ian A. York) wrote:


> Certainly, and I don't want to seem dogmatic about asserting that the DNA 
> is *only* in the muscle cells, or that the CTL response is entirely to 
> the muscle cells.  Note, though, that one thing CD4 does do is interact 
> with MHC II.  The CD4- Th cells are not going to have this restriction, 
                                      ^^^                ^^^^^^^^^^^^^^^
Dear Ian
why shouldnt they ?
If commitment to CD4 or CD8 cells is (partially ?) random in the thymus,
some high affinity/avidity class II restricted cells might make it to
the periphery without contribution of CD4.
I think there needs to be some experimental proof, if it hasnt been done,
before one might say so.

jorg

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Joerg Kirberg                     EMAIL: kirberg at bii.ch
Basel Institute for Immunology    FAX:   41-61-605 13 72
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