Reverse transcriptases

[Ulrich Melcher]

bap at MED.PITT.EDU (Bruce Phillips) wrote:
>
>Does
>anyone with expertise in something other than guns know if there are 
>experimental data concerning the error-proneness of oncovirus RTs? 
 
Is the NRA on this group due to a transposition from RNA? ;-)

Serioously, try these two references for starters:

1. Yu, H. & Goodman, M. F. (1992).  Comparison of HIV-1 and avian 
myeloblastosis virus reverse transcriptase fidelity on RNA and DNA 
templates.  J Biol Chem 267: 10888-10896.
2. Williams, K. J. & Loeb, L. A. (1992).  Retroviral reverse 
transcriptases:  Error frequencies and mutagenesis.  Curr Top Microbiol 
Immunol 176: 165-180.

Ulrich Melcher
Dept Biochem Mol Biol
Oklahoma State Univ