Regarding the infectivity of naked DNA

[Pearse Ward]

In article <3pvbvp$5rv at hermod.uio.no>, ohungnes at bioslave.uio.no (Olav
Hungnes) wrote:


> In the epidermal gene gun-system I feel that the APCs (read:
> Langerhans cells) must be more directly involved.
> 
> Olav

I have a sneaking suspicion that the same may be true of the IM injection
protocol. Those injections go through skin, and I'm sure that the DNA is
leaked into the epidermis and the dermis.

Although, as Ian York pointed out in his latest post, local trauma at the
injection site may very well be important in providing some sort of
adjuvant effect.

Pearse