Regarding the infectivity of naked DNA

[Pearse Ward]

In article <3ptjoj$7hn at cisunix1.dfci.harvard.edu>,
york at mbcrr.dfci.harvard.edu (Ian A. York) wrote:
> Rahemtulla A.  Fung-Leung WP.  Schilham MW.  Kundig TM.  Sambhara 
> SR. Narendran A.  Arabian A.  Wakeham A.  Paige CJ.  Zinkernagel RM.  et al
> Normal development and function of CD8+ cells but markedly 
> decreased helper cell activity in mice lacking CD4.
> Nature.  353(6340):180-4, 1991

> Rahemtulla A.  Shahinian A.  Kundig T.  Zinkernagel R.  Mak TW.
> CD4 negative mice as a model for immunodeficiency.
> Philos Trans R Soc Lond B Biol Sci.  342(1299):57-8, 1993

In these very artificial mouse models, the gene for CD4 has been
disrupted. While it has been shown that CD4 is a marker for the Th subset,
it has not been conclusively shown that in this model system the CD4- Th
cells cannot provide some (albeit reduced) help in the absence of CD4.

Pearse

(P.S. I'm deleting the synopses, only because my nntp server will not
allow me to post more quoted text than original text.)