a molecular evolution question re ebola
salamon at notmendel.Berkeley.EDU
Tue May 23 22:36:46 EST 1995
By the way, note the following.
Perhaps this will be a magnet for the some of the more chatty
posts:
alt.current-events.epidemics
I am not a virologist, but I am a biologist. Sorry if another
question about ebola is irritating, but I think this is appropriate
to this group:
Has anyone access to the molecular data that led to reports that
this latest Ebola zaire outbreak is due to virus little changed over
the past 20 years?
I'd like to see that data.
Where could this virus have been where it did not experience
much genetic drift? Any ideas?
I am ignorant on one point (well, perhaps more than one :) ):
Does Ebola (or do filoviruses in general) use reverse trascriptase?
Can it exist as a provirus? That could slow the accumulation
of substitutions. But something tells me I've heard it doesn't
integrate itself into host DNA.
Is it surprising that it hasn't changed much, and does anyone
have any numbers? I imagine the only data characterizing
Ebola zaire sequence polymorphism
is at most three or four sequences...
Hugh
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