(Fwd) Re: Pathogen-immune cell interactions!

[DANDERSON at PRL.PULMONARY.UBC.CA]

>>In article <105180324EA at prl.pulmonary.ubc.ca> DANDERSON at PRL.PULMONARY.UBC.CA writes:
>>I would be interested in discussing work performed with viruses or 
>>other pathogens, specifically, interactions and associations with 
>>immune cells both in vivo and in vitro and the consequences of such!  

>That's a pretty broad field.  Can you be more specific in your interests?

>Ian

Yes, specifically if anyone has localized viral genome within 
particular regions of the spleen and lymph node via in situ 
hybridization or in situ PCR  I am aware of the HIV, SIV, MCMV and 
LDHV work, but as of yet, not many other intracellular organisms.

I am also interested in the selective migration of  
immune cells into the different immune compartments.  Does the 
architecture of the spleen or LN change during infections which is 
not characteristic of a normal antigenic response???  What is 
migration pattern of monocytes (and other APCs), T-cells, NK-cells 
and  B-cells into and out of the splenic follicle and LN in an 
infected  animal?  Is there work to suggest differential migration 
(infected vs. uninfected), and if so is this change associated with 
functional alterations???   

Thanks,

Dan Anderson