Regarding the infectivity of naked DNA

[Ian A. York]

In article <wardp-2205951312040001 at oisin.usask.ca> wardp at herald.usask.ca (Pearse Ward) writes:
>
>What's the evidence that said mice were protected by muscle cells
>expressing viral proteins, as opposed to say APC's taking up the DNA? I

Some of the papers explicitly show that the muscle cells express the gene 
of interest.  It seems almost impossible that some APC is not also 
transfected at very low frequency and that they are responsible for the 
protection; but the simpler explanation is preferred.

Ian
-- 
Ian York   (york at mbcrr.harvard.edu)
Dana-Farber Cancer Institute, 44 Binney St., Boston MA 02115
Phone (617)-632-3921     Fax  (617)-632-2627