Effect of acyclovir on HHV6/HHV8?

[Jeffrey Johnston]

Given recent suggestions that human herpesvirus-6 (HHV-6) and/or HHV-8 
may mediate disease progression or expression in HIV infected persons, 
has anyone seen any studies comparing whether HIV-associated illness 
progresses differently in those taking acyclovir (or any of the new 
analogs, e.g., famcyclovir, valacyclovir) compared with individuals not 
taking these drugs?  I confess that I haven't seen evidence that these drugs 
have a therapeutic effect on other herpesviridae. If such studies have 
not been done, I suspect these data are available amidst the many 
treatment trials and just waiting to be analyzed. 
 
Jeff Johnston, epidemiology UNC-Chapel Hill