Re infectivity of naked viral DNA
A. M. Lotto
aurelia at u.washington.edu
Thu May 18 16:51:23 EST 1995
I was reading that caulimo viruses might be used to introduce desireable
genes into plants. They are also said to be structurally and
functionally very similar to HBV. I would assume then that caulimo
viruses like HBV form integrates with the host genome on occasion.
A couple of questions have occured to me. First of all, is the mechanism
for the formation of this integrate known yet? Second, the result of HBV
integration into the host human genes is hepatocellular cancer(or so it
is believed by the authors of this book, possibly in conjunction with a
carcinogenic co-factor), what is the result in plants?
HBV persist long and hard in humans, so is this integration a form of
latentcy? Can the virus be 'cured' later from the genome?
If caulimovirus DNA is infectious on its own, does this also hold true
for HBV? It is my understand there is a circular RNA (hepatitis
delta agent) associated with HBV that is compared with a
viroid. Do caulimo viruses also contain this circular RNA?
I would be interested in any info anyone might provide.
Amy Lotto
aurelia at u.washington.edu
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