Need info on HIV 1 RT

[SOG]

From: sawyer.19 at postbox.acs.ohio-state.edu (SOG)

I would like to know if anyone out there is currently researching the HIV 1 RT 
enzyme. I am doing a paper on this protein and a I am in the beginning stages 
but am finding it a little difficult finding beginning research papers on 
this. 

I would like to know where this enzyme is originates. Is it naturally occuring 
within the virus and then is released with conjugation? could it possibly be 
a mutated form of another RT because there are conserved Asn.'s? could the 
cell produce this protein in response to viral genome? What role does the 
single Mg2+ play in the protein? How much could the crystal structure 
(x-crystallography) differ from the structure in solution?; could the solvent 
play important part in decreasing or increasing steric hindrance creating a 
more optimal binding site?

These are just some of the questions that I have to tackle and would love any 
help from good sources. I have been scanning Medline and Bio Resources and 
have some good success but would like to here from first hand sources working 
with this enzyme. 

Finally, I can't seem to find the proposed structure of HIV 1RT submitted by 
Dr. Steitz of Yale. If anyone can help me with this I only have 2 1/2 weeks to 
complete this paper. Thanks  very much.

Lee Anthony Lontoc
sawyer.19 at postbox.acs.ohio-state.edu
614-299-0389

PS. Please suggest papers to review that you might think would help. Please 
email me as I don't get this newsgroup often. :-)

***************************************************
"You cannot sedate all the things you hate"                                
                                 Marilyn Manson                
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***************************************************
"You cannot sedate all the things you hate"                                
                                 Marilyn Manson                






***************************************************
"You cannot sedate all the things you hate"                                
				 Marilyn Manson                
 ***************************************************