Infectious DNA

[Larry W. Cress 443-7173]

Regarding the question of whether pure viral DNA can result in infections 
when injected into animals, see Letvin, et. al. Nature, Volume 349, page 
573, Feb 14, 1991.  They injected 200 micrograms of purified simian 
immunodeficiency virus (SIV) DNA into each of four monkeys.  Three of the 
animals developed a positive blood test for antibodies against SIV, and 
intact viral particles were found in blood cells.  These viral particles 
were further able to infect blood cells from healthy monkeys.

Viral DNA can certainly be infectious, and should be treated with respect 
and caution.