Repost re: possible reservoir for Ebola/Marburg

[Don Haut]

In article <Pine.A32.3.91.950515084607.54284D-100000 at umabnet.ab.umd.edu>,
mremingt at UMABNET.AB.UMD.EDU ("Mary P. Remington") wrote:

> Perhaps the RNA would be lost but, the proviral DNA (assuming Ebola 
> behaves as for instance other Lentiviruses) could persist and if 
> incorporated into a cell or wound become infectious.

I was not under the impression that Filoviruses were Lentiviruses. 
Further, in the model proposed by Feldmann, et al, there is no DNA
intermediate even in replication.  As you know, the virus is a single
segment of minus sense RNA, from this the viral RNA dependant RNA Pol.
makes a plus sense RNA and from this viral genomes are made.

Don

Don Haut 
Molecular Microbiology and Immunology
University of Missouri-Columbia
C601591 at showme.missouri.edu