(Fwd) RNA Genetic drift

[DANDERSON at PRL.PULMONARY.UBC.CA]

In article <566E892421 at prl.pulmonary.ubc.ca> you write:
>......
>An example of just how stable RNA viruses can be is Rubella.  Strains 
>of this virus have been passaged in different laboratories for years 
>with no genetic changes, unless forced.
>Dan

chatski carl <chatski at gl.umbc.edu> wrote:

>Thanks for you informative post.  I am a mathematical logician with an
>interest in this area.  How does one 'force' changes during serial
>passage?  A few words and/or references would be greatly appreciated.

>Thanks - Carl

Many of papers were published with different viral models in the 
60's and 70's concerning virus adaptation.  Some of these were 
performed in laboratories utilizing cold (30, 35 degrees C) and warm 
(40 degrees C) incubators.  As well, other methods for selecting 
viral varients has been utilizing antibodies and developing antibody 
escape mutants.  Searching for virus adaptation and mutants will get 
you a number of articles within those years.  If not I will find some 
specific articles for you!

Dan