Dogs with HIV?

[Sandra Russell]

In <3rp29l$j0o at miasun.med.miami.edu> tmiller at newssun.med.miami.edu (Todd 
Miller - Pharmacology) writes: 

>
>I wonder what the basis of the following observations are.  Obviously,
>there is some kind of (non-specific?) cross reaction, but...
>
>Unique Identifier
>  90352614
>Authors
>  Strandstrom HV.  Higgins JR.  Mossie K.  Theilen GH.
>Institution
>  College of Veterinary Medicine, Helsinki, Finland.
>Title
>  Studies with canine sera that contain antibodies which recognize 
human
>  immunodeficiency virus structural proteins.
>Source
>  Cancer Research.  50(17 Suppl):5628S-5630S, 1990 Sep 1.
>Abstract
>  In a serological survey, using the immunoblotting technique, we found 
that
>  substantial numbers of dog sera from both normal and diseased dogs,
>  including dogs with neoplasia, reacted with one or more human
>  immunodeficiency virus (HIV) recombinant proteins. A total of 144 dog 
sera
>  were tested, and 72 (50%) of them reacted with one or more HIV 
recombinant
>  structural proteins. Ten dog sera were also tested for reactivity 
with
>  simian immunodeficiency virus (SIV), feline immunodeficiency virus 
(FIV),
>  and caprine arthritis encephalitis virus (CAEV). Six dog sera reacted 
with
>  at least the major core protein of HIV, while one of the dog sera 
tested
>  reacted with SIV core protein, and there were no reactions with the 
viral
>  proteins of either FIV or CAEV. Cell extracts from canine peripheral 
blood
>  lymphocytes cocultivated with human cells and an extract of human 
cells
>  infected with HIV were immunoblotted against dog sera which 
previously
>  tested positive or negative on HIV recombinant protein commercially
>  available Western blot strips. Two lymphocyte lysates and the 
HIV-infected
>  Hut cell lysate reacted with the Western blot strip-positive dog 
serum;
>  however, no reactions were seen with the Western blot strip-negative 
dog
>  serum.
>
>
>
>

Todd, there is a specific lentivirus for cows, sheep, goats, horses, 
cats, monkeys, and humans.  It would surprise me very much if there was 
no cainine strain, and here we may be seeing the first spoor of it.



                                             Steve Harris, M.D.