Dogs with HIV?
Todd Miller - Pharmacology
tmiller at newssun.med.miami.edu
Thu Jun 15 05:33:25 EST 1995
I wonder what the basis of the following observations are. Obviously,
there is some kind of (non-specific?) cross reaction, but...
Unique Identifier
90352614
Authors
Strandstrom HV. Higgins JR. Mossie K. Theilen GH.
Institution
College of Veterinary Medicine, Helsinki, Finland.
Title
Studies with canine sera that contain antibodies which recognize human
immunodeficiency virus structural proteins.
Source
Cancer Research. 50(17 Suppl):5628S-5630S, 1990 Sep 1.
Abstract
In a serological survey, using the immunoblotting technique, we found that
substantial numbers of dog sera from both normal and diseased dogs,
including dogs with neoplasia, reacted with one or more human
immunodeficiency virus (HIV) recombinant proteins. A total of 144 dog sera
were tested, and 72 (50%) of them reacted with one or more HIV recombinant
structural proteins. Ten dog sera were also tested for reactivity with
simian immunodeficiency virus (SIV), feline immunodeficiency virus (FIV),
and caprine arthritis encephalitis virus (CAEV). Six dog sera reacted with
at least the major core protein of HIV, while one of the dog sera tested
reacted with SIV core protein, and there were no reactions with the viral
proteins of either FIV or CAEV. Cell extracts from canine peripheral blood
lymphocytes cocultivated with human cells and an extract of human cells
infected with HIV were immunoblotted against dog sera which previously
tested positive or negative on HIV recombinant protein commercially
available Western blot strips. Two lymphocyte lysates and the HIV-infected
Hut cell lysate reacted with the Western blot strip-positive dog serum;
however, no reactions were seen with the Western blot strip-negative dog
serum.
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