How can I cure Herpes

Ian A. York york at mbcrr.dfci.harvard.edu
Fri Jun 2 07:40:20 EST 1995


In article <grad-0106951624250001 at 137.131.48.69> grad at scripps.edu (grad student) writes:
>
>But, even in latency, isn't the viral DNA still being transcribed by the
>host? If so, then some novel non-self proteins should be formed, degraded,
>and presented on the cell surface. A humoral or T cell attack could be
>directed against such herpes peptides...

(1) No, in latency there are probably no proteins expressed (a little 
debate but fairly confident)
(2)  Anyway, latency is in neurons, which don't express MHC I well anyway
(3)  HSV has a specific mechanism to block MHC I presentation on top of 
all that.

Ian
-- 
Ian York   (york at mbcrr.harvard.edu)
Dana-Farber Cancer Institute, 44 Binney St., Boston MA 02115
Phone (617)-632-3921     Fax  (617)-632-2627




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