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[Richard Spaete]

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To "grad student":  I'll put this out on the net because I couldn't get it to
you directly.

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Date: 6/1/95 6:40 PM
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Date: 1 Jun 1995 17:45:33 U
From: "Richard Spaete" <spaete at biomail.aviron.com>
Subject: Re: How can I cure Herpes
To: "grad student" <grad at scripps.edu>

        Reply to:   RE>>How can I cure Herpes
Only a select region of the genome is transcribed during latency and viral
products have not been demonstrated from these transcripts.  The virus persists
even in the presence of a fully competent humoral and cellular response.  In the
latent state, some workers have reported a CD8+ CTL response to virus in neurons
is beneficial in maintaining the latent virus (mechanism undefined).  Also
recall that neurons don't express class I HLA molecules anyway....so any benefit
or killing would not be direct.  It was also once thought that viral replication
inevitably resulted in the death of the neuron.  This is no longer believed.

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Date: 6/1/95 5:04 PM
To: Richard Spaete
From: grad student
In article <3qh5kj$fro at newsbf02.news.aol.com>, yelnif at aol.com (Yelnif) wrote:

> sorry, no cure.  Herpes is a latent virus and reoccurance of the virus is
> just a fact of life.  The drug acyclover will stop the reoccurances faster
> than your own immune system can but will not kill the latent infection.

But, even in latency, isn't the viral DNA still being transcribed by the
host? If so, then some novel non-self proteins should be formed, degraded,
and presented on the cell surface. A humoral or T cell attack could be
directed against such herpes peptides...

Erica Ollmann
The Scripps Research Institute