spontaneous mutation rate in RNA viruses

[ryan at mbcf.stjude.org]

In article <9302191428.AA14397 at net.bio.net>, mperdue at ASRR.ARSUSDA.GOV
 ("MICHAEL PERDUE") writes:
> Is anyone currently doing research on rates of spontaneous mutations
> in RNA viruses?

Hello Mike:
Several groups are working on this topic. One of the more long-running and
productive groups is that of John Holland. See for example

	D.A Steinhauer, E. Domingo, J.J.Holland (1992)
	Lack of evidence for proofreading mechanisms
	associated with an RNA virus polymerase.
	GENE 122:281-288.

This paper and references cited therein should get you started.
Cheers,
Kevin.
==========================================
Kevin W. Ryan
Department of Virology & Molecular Biology
St. Jude Children's Research Hospital
Memphis, Tennessee, U.S.A.
  phone (901) 522-0411, fax (901) 523-2622
    Internet: ryan at mbcf.stjude.org
==========================================