Recent changes to this wiki:
fix hedonic reward encoding modification proposal; encode neuronal protein bits for brain uploading reasons.
nutrition: framing: consider microbiome and exo-metabolome
Changed pages:
nutrition/gv/nutrient-sensing-glutamate-training.gv
Changed by: kanzure
Commit type: git
Date: 08:00:28 10/02/25
fix typo about supraphysiology
nutrition: framing: rephrase meta-objective shift to be more present-tense.
fix broken nutrition link
Changed pages:
brain imaging
brain uploading
genetic-modifications
mapseq
Changed by: kanzure
Commit type: git
Date: 07:52:24 10/02/25
add germline modification targets:
* real-time optogenetic increase of working memory capacity.
* use optogenetic activation of dopamine D1 or D2 receptor-expressing
striatal projection neurons to influence reinforcement learning.
* nucleus accumbens optogenetic targets for reward or reinforcement in
classical conditioning, pavlovian conditioning, operant conditioning,
etc.
* add note about microvoltage electroreception for EEG either in
afferent neurons or in the brain for non-synaptic activation coupling.
* add note about magnetoreception or magnetoception might be a plausible
brain-computer interface technique to consider.
* write outline of a scheme for multiplex DREADDs for cell-type-specific
retargeting of transient optogenetic receptor expression.
Update the disclaimer at the top about how to science or reason about
any of the information in the document. Admittedly there is lots of
noise.
* real-time optogenetic increase of working memory capacity.
* use optogenetic activation of dopamine D1 or D2 receptor-expressing
striatal projection neurons to influence reinforcement learning.
* nucleus accumbens optogenetic targets for reward or reinforcement in
classical conditioning, pavlovian conditioning, operant conditioning,
etc.
* add note about microvoltage electroreception for EEG either in
afferent neurons or in the brain for non-synaptic activation coupling.
* add note about magnetoreception or magnetoception might be a plausible
brain-computer interface technique to consider.
* write outline of a scheme for multiplex DREADDs for cell-type-specific
retargeting of transient optogenetic receptor expression.
Update the disclaimer at the top about how to science or reason about
any of the information in the document. Admittedly there is lots of
noise.
nutrition: framing: exploratory intervention framing
Changed pages:
nutrition/gv/nutrient-sensing-glutamate-training.gv
Changed by: jrayhawk
Commit type: git
Date: 07:30:14 10/02/25
nutrition: graphviz: notes and chromium exclusion
Changed pages:
nutrition/gv/nutrient-sensing-glutamate-training.gv
Changed by: jrayhawk
Commit type: git
Date: 06:06:27 10/02/25
nutrition: gv: minor updates to notes
Revert ""
This reverts commit 9e0b47d4a7e3dd2a8a51856edc7fa225bb5710d3.
This reverts commit 9e0b47d4a7e3dd2a8a51856edc7fa225bb5710d3.
Changed pages:
nutrition/gv/nutrient-sensing-glutamate-current.gv
nutrition/gv/nutrient-sensing-sodium-current.gv
nutrition/gv/nutrient-sensing-sodium-training.gv
Changed by: jrayhawk
Commit type: git
Date: 17:12:37 10/01/25
nutrition: graphviz: remove extraneous comments
nutrition: framing: fix ordered list syntax
Changed pages:
nutrition/framing
nutrition/gv/nutrient-sensing-glutamate-current.gv
nutrition/gv/nutrient-sensing-glutamate-training.gv
nutrition/gv/nutrient-sensing-sodium-current.gv
nutrition/gv/nutrient-sensing-sodium-training.gv
Changed by: jrayhawk
Commit type: git
Date: 16:10:27 10/01/25
nutrition: framing: satisfy idiosyncratic ikiwiki requirements
Changed pages:
nutrition/framing
nutrition/gv/nutrient-sensing-glutamate-current.gv
nutrition/gv/nutrient-sensing-glutamate-training.gv
nutrition/gv/nutrient-sensing-sodium-current.gv
nutrition/gv/nutrient-sensing-sodium-training.gv
Changed by: jrayhawk
Commit type: git
Date: 14:50:14 10/01/25
nutrition: framing: add examples of physiological and pathological mesa-alignment
nutrition: framing: fix citation
Changed pages:
nutrition-and-physiology-engineering
nutrition/framing
Changed by: jrayhawk
Commit type: git
Date: 14:05:49 10/01/25
nutrition and physiology: rename to framing
use xenobiotic cathelicidin as an antimicrobial, use horseshoe antimicorbial bloodcotting defense via rapid enzymatic polymerization instead of interferon begging, sleep neurons
consider more genetic changes for brain-computer interfaces
fix mapseq page, move connectome-seq
oops fix cell lineage tracing link
Changed pages:
brain imaging
brain uploading
genetic-modifications
mapseq
Changed by: kanzure
Commit type: git
Date: 19:10:56 09/30/25
germline upgrades to assist with brain uploading
add links for consensus-based genomic integrity strategy stuff
use cell-cell genome consensus validation for DNA damage repair
uterine denervation
suppress or activate feeding neurons, thirst neurons, social status gene, gay gene
delayed puberty, puberty blocking, eliminate menstruation pain
Changed pages:
nutrition-and-physiology-engineering
Changed by: jrayhawk
Commit type: git
Date: 12:24:16 09/27/25
nutrition/physiology engineering: initial problem statement and outline
nutrition: typo
nutrition: various corrections
genetic-modifications: s/septin/seipin/
add motivation, reward, euphoria, anti-depression, etc
Changed pages:
brain imaging
gene-editing
gene-therapy
genetic-modifications
in vitro fertilization
Changed by: kanzure
Commit type: git
Date: 14:53:42 09/26/25
mooore
more bone stone
edit PON1
PON1
phytase and k2
type 1 and type 2 are very different diseases, best not to mix them up
a little reorganizing
add genetic routes for increased dizygotic twinning, speculate about monozygotic twinning
Changed pages:
genetic-modifications
mitochondria
Changed by: kanzure
Commit type: git
Date: 14:01:04 09/21/25
explain why extra peripheral nervous system nerve fibers and roots, add hair color
Changed pages:
genetic-modifications
mitochondria
mitochondria longevity
transcripts/genetically-encoded-oscillatory-waves
transcripts/scalingbitcoin/hong-kong/segregated-witness-and-its-impact-on-scalability
Changed by: kanzure
Commit type: git
Date: 13:05:48 09/21/25
various changes:
* SCN9A mutations for pain insensitivty are now better documented,
including some non-SCN9A mutations.
* various longevity changes, mutations and targets.
* an analysis of eight's original "how aging work's" document, with
proposed germline modifications.
* mitochondria longevity page is split out and included in the germline
modifications page and mitochondria page.
* naked mole rat hyaluronic acid stuff.
* transcript for the conference talk on genomically encoded oscillatory
waves as a way to extract data from cells.
* SCN9A mutations for pain insensitivty are now better documented,
including some non-SCN9A mutations.
* various longevity changes, mutations and targets.
* an analysis of eight's original "how aging work's" document, with
proposed germline modifications.
* mitochondria longevity page is split out and included in the germline
modifications page and mitochondria page.
* naked mole rat hyaluronic acid stuff.
* transcript for the conference talk on genomically encoded oscillatory
waves as a way to extract data from cells.
Changed pages:
genetic-modifications
transcripts/longevity-comparative-biology-gorbunova
Changed by: kanzure
Commit type: git
Date: 08:44:05 09/21/25
whale SIRT6 transcript
sensory hyperinnervation and muscle hyperinnervation
reorganize table of contents
muscle hyperplasia, more intelligence alleles, various minor changes
add ADAM12 mutants associated with high IQ (2018)
improve eye color genetics, immune system, autoimmune disease protection, etc
add a note about human cloning
more reorg
reorganize
huh, infrared vision is pretty hard
add selegiline-related longevity genetics, fix table of contents
add hedonistic imperative david pearce germline recommendations
various germline enhancements for longevity, anti-aging, rejuvenation, senolysis, etc
Changed pages:
extra ovaries
genetic-modifications
Changed by: kanzure
Commit type: git
Date: 16:21:57 09/16/25
fertility enhancement via oogonial stem cell proliferation; add whole-body regeneration capability to germline.
reorganize the genetic modifications file
reorganize some of the muscle genetics for endurance vs strength
Changed pages:
genetic-modifications
organoids
Changed by: kanzure
Commit type: git
Date: 15:14:05 09/15/25
hearing range enhancement notes
Changed pages:
brain uploading
genetic-modifications
Changed by: kanzure
Commit type: git
Date: 15:02:57 09/15/25
add downloadable immunity scheme, and an anti-viral scheme
hair follicles and cell surface-bound protein filaments as information recorders for debugging
Changed pages:
genetic-modifications
organoids
Changed by: kanzure
Commit type: git
Date: 08:03:05 09/15/25
olfactory enhancements
add wooly mouse genes and caution on MC1R
Changed pages:
users/fenn/colossal 1a hair-or8.png
Changed by: fenn
Commit type: git
Date: 15:37:21 09/14/25
colossal wooly mouse gene effects fig. 1A file size reduced with pngquant --nofs 32
colossal wooly mouse and wild type closeup 40% quality
TODO: embryological platform for control over progenitor cell proliferation across any tissue or organ
destroy the height polygeneity-maximalists
Changed pages:
cell-specific expression
genetic-modifications
mitochondria
Changed by: kanzure
Commit type: git
Date: 13:32:07 09/13/25
how to make a genetic genotype sensor gene circuit
Changed pages:
cell-specific targeting
cell therapy
cloning
gene-editing
genetic-modifications
neuroscience
sleep
Changed by: kanzure
Commit type: git
Date: 12:33:16 09/13/25
programmable horizontal gene transfer and cell-specific targeting
Changed pages:
cell therapy
genetic-modifications
Changed by: kanzure
Commit type: git
Date: 17:53:15 09/09/25
HLA-g stuff, feto-maternal stem cells, fertility upregulation genetic changes, delayed age of menopause phenotype
spontaneous mitochondrial transfer
Changed pages:
cell-specific expression
genetic-modifications
immune system
Changed by: kanzure
Commit type: git
Date: 07:06:41 09/08/25
more cognitive enhancement targets: MCPH1, BEC1/KCNH3 knockout, SP0535, NOTCH2NL overexpression, PSD-95 overexpression
add cute image of a mitochondrion
Changed pages:
users/fenn/mitochondrion diagram en.png
users/fenn/mitochondrion diagram en.svg
Changed by: fenn
Commit type: git
Date: 21:50:32 09/07/25
can't be bothered to jump through the hoops necessary to upload my fixes to wikipedia so adding it here instead. license is CC0
Changed pages:
cell-specific expression
cell therapy
gene-editing
genetic-modifications
xenotransplantation
Changed by: kanzure
Commit type: git
Date: 13:37:32 09/07/25
more cell-specific expression technologies
import 10+ years of updates from george church wishlist
Changed pages:
cell therapy
genetic-modifications
xenotransplantation
Changed by: kanzure
Commit type: git
Date: 09:01:23 09/07/25
more brain stuff
Changed pages:
biosight
blastocyst complementation
cell therapy
diabetes
hplusroadmap
in vitro fertilization
xenotransplantation
Changed by: kanzure
Commit type: git
Date: 19:33:23 09/06/25
immune system engineering
Changed pages:
brain imaging
distillation
genetic-modifications
human brain reverse engineering
intelligence
Changed by: kanzure
Commit type: git
Date: 08:50:41 09/06/25
deubiquitination theory of learning
Changed pages:
genetic-modifications
mitochondria
neurosurgery
Changed by: kanzure
Commit type: git
Date: 02:34:46 09/06/25
more cognitive genetic modifications
artificial womb refs
Changed pages:
DNA data storage
DNA nanoscopy
DNA sequencing
DNA ticker tape
ant routing
artificial life
bioprinting
biosight
brain imaging
brain uploading
...
Changed by: kanzure
Commit type: git
Date: 12:26:14 09/04/25
add various references
inline the brain biochip image
Changed pages:
users/fenn/BAA09 16 brain bio-chip.png
Changed by: fenn
Commit type: git
Date: 01:52:44 09/04/25
desty nova tiphares brain chip reveal
more gene editing systems
Changed pages:
DNA nanoscopy
DNA sequencing
azobenzene
cloning
cryonics
diabetes
fisseq
gene-editing
hplusroadmap
in situ sequencing
...
Changed by: kanzure
Commit type: git
Date: 09:35:30 09/03/25
various exciting updates
Changed pages:
brain
cell therapy
gene-editing
gene-therapy
genetic-modifications
in vitro fertilization
nerve graft
neurosurgery
reservoir computing
sleep
...
Changed by: kanzure
Commit type: git
Date: 11:50:28 09/01/25
lotta changes related to cell therapy, gene therapy, sleep, brain
try fix inlineing
Changed pages:
cell therapy
gene-therapy
Changed by: kanzure
Commit type: git
Date: 10:23:51 09/01/25
trying inline
Changed pages:
DNA nanoscopy
brain uploading
expansion microscopy
fisseq
gene-therapy
in-situ-sequencing
in situ sequencing
lineage tracing
mapseq
protein engineering
Changed by: kanzure
Commit type: git
Date: 10:19:30 09/01/25
intracellular imaging via in situ sequencing
Changed pages:
DNA ticker tape
gene-therapy
morphogenesis
protein engineering
Changed by: kanzure
Commit type: git
Date: 17:34:01 08/31/25
small tweaks
Changed pages:
DNA ticker tape
lineage tracing
mapseq
optogenetics
Changed by: kanzure
Commit type: git
Date: 17:12:45 08/31/25
DNA ticker tape memory
Changed pages:
brain uploading
optogenetics
Changed by: kanzure
Commit type: git
Date: 10:50:31 08/31/25
more optogenetics
Changed pages:
brain uploading
gene-editing
gene therapy
human-brain-reverse-engineering
human brain reverse engineering
polymerase/pfam-families
reservoir computing
Changed by: kanzure
Commit type: git
Date: 10:28:32 08/31/25
various updates, also some interesting protein pfam families
Changed pages:
cloning
gene-editing
gene-therapy
gene editing
hplusroadmap
in-vitro-fertilization
in vitro fertilization
index
organoids
protein-engineering
...
Changed by: kanzure
Commit type: git
Date: 10:06:31 08/31/25
rearrange chairs on deck of titanic
Changed pages:
brain uploading
expansion microscopy
fisseq
in-situ-sequencing
Changed by: kanzure
Commit type: git
Date: 09:46:36 08/31/25
expansion microscopy
Changed pages:
DNA nanoscopy
brain uploading
in-situ-sequencing
lineage-tracing
lineage tracing
mapseq
Changed by: kanzure
Commit type: git
Date: 09:15:19 08/31/25
add DNA nanoscopy references.
try underscores for whitespace filenames.
add a brain uploading page that points to FISSEQ.
try underscores for whitespace filenames.
add a brain uploading page that points to FISSEQ.
and mapseq
Changed pages:
bioprinting
cloning
fisseq
gene-editing
in-situ-sequencing
in-vitro-fertilization
lineage-tracing
octopus
optogenetic-axon-guidance
Changed by: kanzure
Commit type: git
Date: 14:48:05 08/30/25
3d bioprinting, cloning, FISSEQ, MAPseq, BARseq, in situ sequencing, lineage tracing, etc